He said Google and Facebook had already lent their backing to the project, which aims to create a technology hub running from Old Street to the Olympic Park.
Google has agreed to create an innovation hub in east London, while Facebook has agreed to create a permanent home for developers and entrepreneurs here in the UK, Cameron said.
US technology firm Intel had also agreed to set up UK bases in the area while the planned installation of super-fast broadband in east London is to be brought forward, although details are yet to emerge.
"Our ambition is to bring together the creativity and energy of Shoreditch and the incredible possibilities of the Olympic Park to help make east London one of the world's great technology centres," Cameron said.
Cameron said the Olympic Park Legacy Company, which is the organisation responsible for delivering the 2012 legacy, had agreed to provide office space in the Olympic Park to businesses that set themselves up in east London.
Regeneration & Renewal's Fair Games campaign seeks to ensure that the regeneration pledges made in relation to the Games are honoured. For more details, visit regen.net/fairgames