Covering 20 hectares of brownfield land along the River Nene, the site includes a disused factory owned by Avon Cosmetics and a former power station owned by housebuilders Taylor Wimpey and Persimmon.
The proposed CPO also covers an area of land in unknown ownership, which is required for a new road.
The WNDC said work is already under way at nearby sites in the enterprise zone, including a bottling plant for Carlsberg UK which was granted planning approval in January. Construction of a new and improved railway station in the centre of the zone will begin next year after the Department for Transport approved £10 million in funding for the project in May.
The Northampton Waterside Enterprise Zone, which covers 120 hectares of brownfield land, was designated by the government in August 2011.
The public inquiry will start on 13 November and is anticipated to run for approximately two weeks. It is expected be held at Franklin’s Gardens, Northampton.