The document will act as the local planning policy for making decisions on the future development of vacant land, the re-use of key buildings and the improvement of streets and spaces, the council said in a statement.
It also aims to support the Barras market to become a "hub which attracts new businesses and supports innovation and entrepreneurship", according to the council.
Bailie Liz Cameron, executive member for jobs and the economy at Glasgow City Council, said: "Calton and the Barras have historically played a key role in the development of Glasgow, and this framework points the way for their future regeneration.
"The area has many assets, particularly in its location - close to the city centre and the massive potential now being unlocked in the East End - and its future development will benefit both local people and businesses and the economy of Glasgow as a whole."
The Calton Area Development Framework can be read here.